The Role of Interleukin 10 Genetic Variations in Pulmonary Tuberculosis: Perspectives of Genetics, Pathogenesis and Immunology

Debie Anggraini


Pulmonary tuberculosis remains a significant global public health challenge. In efforts to overcome this disease, a deeper understanding of the role of individual genetics, such as IL-10 genetic variation, in the response to M. tuberculosis infection is critical. Research that has been conducted shows that IL-10, which has an important role in regulating the immune response, can also influence the development of TB. Genetic variations in the IL-10 gene play a role in determining the extent of the immune response to TB infection and an individual's risk of this disease. The interaction between Treg cells, IL-10, and TB is also an important aspect in the pathogenesis and management of TB. Although Treg cells and IL-10 have a role in controlling excessive inflammation, too much of either can dampen the immune response needed to overcome infections. The implication of this research is that the development of more targeted and personalized therapy is an important step in overcoming TB. The use of individual genetic knowledge, such as IL-10 genetic variations, can help design more effective therapies and improve patient prognosis. However, challenges such as drug resistance and the complexity of genetic-immunological interactions remain challenges that need to be overcome in TB management. Overall, this study shows the importance of involving the fields of genetics and immunology in global efforts to address pulmonary tuberculosis. With a deeper understanding of the factors that influence the immune response to TB infection, we can hope to develop more effective strategies in the prevention, diagnosis and treatment of this disease and reduce the burden of TB worldwide.


Interleukin 10; Pulmonary Tuberculosis; Genetic Variation, Pathogenesis; Immunology

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Anggraini D, Nasrul E, Susanti R, Suharti N. Polymorphysm of tumor necrosis factor-Α interleukin-10 gene with pulmonary tuberculosis susceptibility. J Popul Ther Clin Pharmacol. 2023;30(2):50–8.

Commentary S, Review S, Review S, Review S, Review S, Redford PS, et al. The role of IL-10 in immune regulation during M . tuberculosis infection. Soc Mucosal Immunol [Internet]. 2011;4(3):261–70. Available from:

DiNardo AR, Gandhi T, Heyckendorf J, Grimm SL, Rajapakshe K, Nishiguchi T, et al. Gene expression signatures identify biologically and clinically distinct tuberculosis endotypes. Eur Respir J [Internet]. 2022;60(3). Available from:

Abel L, El-Baghdadi J, Bousfiha AA, Casanova JL, Schurr E. Human genetics of tuberculosis: A long and winding road. Philos Trans R Soc B Biol Sci. 2014;369(1645).

Ahmed A. Emerging patterns of regulatory T cell function in tuberculosis. 2020;273–87.

Bellerose MM. Genetic Identification of Novel Mycobacterium tuberculosis Susceptibility and Survival Mechanisms During Antibiotic Treatment Let us know how access to this document benefits you . 2020;

Sawitri NE, Prasetyo AA, Moewardi R. Polimorfisme Gen IL-10 -1082 G / A Sebagai Faktor Kerentanan Pejamu pada Pasien Tuberkulosis Multidrug Resistant Host Susceptibility Factor In Patients With Multidrug Resistant Tuberculosis. 2014;36(1):1–10.

Seviyelerinin S, Polimorfizminin I--AC, İlaç T. IL-10-592 A / C Gene Polymorphism and Cytokine Levels are Associated with Susceptibility to Drug Resistance in Tuberculosis. 2020;8(3):103–12.

Grigorov B, Trenova AG, Miteva LD, Stanilova SA. Interleukin-10 ( IL-10 ) promoter polymorphism at position – 1082 in Bulgarian patients with multiple sclerosis. 2019;10(April).

Silva CA, Fernandes DCRO, Braga ACO, Cavalcante GC, Sortica VA, Hutz MH, et al. Investigation of genetic susceptibility to Mycobacterium tuberculosis (VDR and IL10 genes) in a population with a high level of substructure in the Brazilian Amazon region. Int J Infect Dis [Internet]. 2020;98:447–53. Available from:

McHenry ML, Bartlett J, Igo RP, Wampande EM, Benchek P, Mayanja-Kizza H, et al. Interaction between host genes and Mycobacterium tuberculosis lineage can affect tuberculosis severity: Evidence for coevolution? PLoS Genet [Internet]. 2020;16(4):1–18. Available from:

Mchenry ML, Williams SM, Stein CM, Sciences QH, Sciences G, Western C. perspectives and approaches. 2021;2020:1–25.

Walker TM, Ip CLC, Harrell RH, Evans JT, Kapatai G, Dedicoat MJ, et al. Whole-genome sequencing to delineate Mycobacterium tuberculosis outbreaks: A retrospective observational study. Lancet Infect Dis [Internet]. 2013;13(2):137–46. Available from:

Wampande EM, Naniima P, Mupere E, Kateete DP, Malone LSL, Stein CM, et al. Genetic variability and consequence of Mycobacterium tuberculosis lineage 3 in Kampala-Uganda. PLoS One. 2019;14(9):1–14.

Ndhlovu V, Kiran A, Sloan D, Mandala W, Kontogianni K, Kamdolozi M, et al. Genetic diversity of Mycobacterium tuberculosis clinical isolates in Blantyre, Malawi. Heliyon [Internet]. 2019;5(10):e02638. Available from:

Peresi E, Ragozo L, Oliveira C, Laurentino W, Alessandra É, Nunes P, et al. Cytokine Polymorphisms , Their Influence and Levels in Brazilian Patients with Pulmonary Tuberculosis during Antituberculosis Treatment. 2013;2013.

Raja A. Immunology of tuberculosis. Indian J Med Res. 2004;120(4):213–32.

Ismail N, Rivière E, Limberis J, Huo S, Metcalfe JZ, Warren RM, et al. Genetic variants and their association with phenotypic resistance to bedaquiline in Mycobacterium tuberculosis: a systematic review and individual isolate data analysis. The Lancet Microbe. 2021;2(11):e604–16.

Anggraini, D., & Oktora, M. Z. (2021). Hematology Profile of Tuberculosis Lymphadenitis Patients at Siti Rahmah Hospital, Padang, Indonesia. Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML), 27(3).



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