The Role of Physical Exercise in Food Intake Suppression

Widia Sari, Neng Tine Kartinah


Obesity is a global health issue since it is related to diseases that are the leading causes of mortality, such as diabetes, stroke, and cardiovascular disease. A long-term imbalance between energy intake and energy expenditure is one of the factors contributing to obesity. In addition to increasing energy expenditure, physical exercise can also aid in weight loss by decreasing food intake. An increase in appetite-regulating hormones (ghrelin, GLP-1, leptin, and adiponectin), myokines (IL-6 and irisin), and lactate mediates the suppression of food intake during physical exercise. These substances function as signals that regulate food intake at the peripheral and/or central nervous system levels. Peripherally, lactate inhibits ghrelin secretion, while IL-6 increases GLP-1 secretion. In the center for regulating food intake, lactate, IL-6, leptin, and adiponectin act by inhibiting the release of orexigenic neuropeptides (NPY/AgRP) and increasing the release of anorexigenic neuropeptides (POMC). This review highlighted the role of physical exercise in overcoming obesity through suppression of food intake mediated by hormones and myokine changes that play a role in regulating food intake either in the periphery or directly in the central nervous system.


Physical Exercise, Food Intake, Orexigenic, Anorexigenic

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Jin X, Qiu T, Li L, Yu R, Chen X, Li C, et al. Pathophysiology of obesity and its associated diseases. Acta Pharmaceutica Sinica B. Chinese Academy of Medical Sciences; 2023.

Alhabeeb H, Alfaiz A, Kutbi E, Alshahrani D, Alsuhail A, Alrajhi S, et al. Gut hormones in health and obesity: The upcoming role of short chain fatty acids. Vol. 13, Nutrients. MDPI AG; 2021. p. 1–20.

Woodward ORM, Gribble FM, Reimann F, Lewis JE. Gut peptide regulation of food intake-evidence for the modulation of hedonic feeding. J Physiol [Internet]. 2022;600:1053–78. Available from:

Lin X, Li H. Obesity: Epidemiology, Pathophysiology, and Therapeutics. Vol. 12, Frontiers in Endocrinology. Frontiers Media S.A.; 2021.

Thackray AE, Deighton K, King JA, Stensel DJ. Exercise, appetite and weight control: Are there differences between men and women? Vol. 8, Nutrients. MDPI AG; 2016.

Gonzalez-Gil AM, Elizondo-Montemayor L. The role of exercise in the interplay between myokines, hepatokines, osteokines, adipokines, and modulation of inflammation for energy substrate redistribution and fat mass loss: A review. Vol. 12, Nutrients. MDPI AG; 2020. p. 1.

Fedewa M V., Hathaway ED, Ward-Ritacco CL, Williams TD, Dobbs WC. The Effect of Chronic Exercise Training on Leptin: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Vol. 48, Sports Medicine. Springer International Publishing; 2018. p. 1437–50.

McCarthy SF, Islam H, Hazell TJ. The emerging role of lactate as a mediator of exercise-induced appetite suppression. Vol. 319, American Journal of Physiology - Endocrinology and Metabolism. American Physiological Society; 2020. p. E814–9.

Islam H, Townsend LK, Mckie GL, Medeiros PJ, Gurd BJ, Tom X, et al. Potential involvement of lactate and interleukin-6 in the appetite-regulatory hormonal response to an acute exercise bout Licensed under Creative Commons Attribution CC-BY 3.0. J Appl Physiol [Internet]. 2017;123:614–23. Available from:

Rodrigues KC da C, Pereira RM, de Campos TDP, de Moura RF, da Silva ASR, Cintra DE, et al. The role of physical exercise to improve the browning of white adipose tissue via POMC neurons. Vol. 12, Frontiers in Cellular Neuroscience. Frontiers Media S.A.; 2018.

Sun J, Gao Y, Yao T, Huang Y, He Z, Kong X, et al. Adiponectin potentiates the acute effects of leptin in arcuate Pomc neurons. Mol Metab. 2016 Oct 1;5(10):882–91.

Jais A, Brüning JC. Arcuate Nucleus-Dependent Regulation of Metabolism-Pathways to Obesity and Diabetes Mellitus. Vol. 43, Endocrine Reviews. Endocrine Society; 2022. p. 314–28.

Fujiwara Y, Eguchi S, Murayama H, Takahashi Y, Toda M, Imai K, et al. Relationship between diet/exercise and pharmacotherapy to enhance the GLP‐1 levels in type 2 diabetes. Endocrinol Diabetes Metab. 2019 Jul;2(3).

van Bloemendaal L, ten Kulve JS, La Fleur SE, Ijzerman RG, Diamant M. Effects of glucagon-like peptide 1 on appetite and body weight: Focus on the CNS. Journal of Endocrinology. 2014 Apr;221(1).

Nay K, Smiles WJ, Kaiser J, McAloon LM, Loh K, Galic S, et al. Molecular mechanisms underlying the beneficial effects of exercise on brain function and neurological disorders. Vol. 22, International Journal of Molecular Sciences. MDPI; 2021.

Jodeiri Farshbaf M, Alviña K. Multiple Roles in Neuroprotection for the Exercise Derived Myokine Irisin. Vol. 13, Frontiers in Aging Neuroscience. Frontiers Media S.A.; 2021.

Torres-Fuentes C, Golubeva A V., Zhdanov A V., Wallace S, Arboleya S, Papkovsky DB, et al. Short-chain fatty acids and microbiota metabolites attenuate ghrelin receptor signaling. FASEB Journal. 2019 Dec 1;33(12):13546–59.

Kistner TM, Pedersen BK, Lieberman DE. Interleukin 6 as an energy allocator in muscle tissue. Vol. 4, Nature Metabolism. Nature Research; 2022. p. 170–9.

Schéle E, Benrick A, Grahnemo L, Egecioglu E, Anesten F, Pálsdóttir V, et al. Inter-relation between Interleukin (IL)-1, IL-6 and Body Fat Regulating Circuits of the Hypothalamic Arcuate Nucleus. J Neuroendocrinol. 2013 Jun;25(6):580–9.

Di Rosa MC, Zimbone S, Saab MW, Tomasello MF. The pleiotropic potential of bdnf beyond neurons: Implication for a healthy mind in a healthy body. Vol. 11, Life. MDPI; 2021.



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