EFEKTIVITAS INJEKSI INTRALESI BEBERAPA JENIS OBAT PADA TERAPI ORAL LICHEN PLANUS : TINJAUAN SISTEMATIK

Adi Ahmad Yusuf, Nanan Nuraeny

Abstract


Introduction: Oral lichen planus (OLP) is a chronic inflammatory disease with unknown etiology. The immune system plays a role in this disease, a sub-epithelial band infiltration is dominated by T lymphocytes and macrophages is visible histopathologically. Stress, genetics, diet, drugs, dental plaque, systemic disease, and poor oral hygiene are thought to trigger OLP. Treatment of this disease usually uses topical corticosteroids in the form of an ointment, mouthwash, spray or paste or systemic corticosteroids, but in some patient there are unwanted side effects of systemic and topical corticosteroids such as moon face and hirsutism. Intralesional corticosteroid injections are topical therapy and can be used to reduce these side effects. The purpose of this systematic review is to provide information on the effectiveness and types of drugs used in the treatment of OLP by intralesional injection. Methods: A literature search was conducted using electronic databases including PubMed and Google Scholar. Only articles in English and Indonesian are included, with keywords intralesional injection, oral lichen planus, and therapy. Cohort study, randomized controlled trial, and research between 2010 and 2020. Results: A total of 1,179 articles were obtained according to the keywords, but after eliminating duplication and screening based on abstracts, 8 articles were obtained, with 4 types of drugs being used for intralesional injection therapy in OLP, namely Triamcinolone acetonide, Bacillus Calmette Guerin-Polysaccharide Nucleic Acid (BCG-PSN), bethametasone and bevacizumab. Conclusion: Intralesional injection with Triamcinolone acetonide, betamethasone, BCG-PSN, and bevacizumab drugs is effective in treating oral lichen planus.

Keywords


injeksi intralesi, oral lichen planus, terapi

References


Alerraqi E. Steroid Therapy in Oral Lichen Planus. J Steroids Horm Sci. 2016;7(2):2–5.

Glick M. Burkets Oral Medicine. Twelfth Ed. Shelton,CT: People’s medical Publishing House-USA; 2015. 175–195 p.

Odell E. Cawson’s Essential Of Oral Pathology and Oral Medicine. 9th Editio. Elsevier Inc.; 2017.

Kyriakis K, Terzoudi S, Palamaras I, Michailides C, Emmanuelides S, Pagana G. Sex and age distribution of patients with lichen planus. J Eur Acad Dermatology Venereol. 2006;20(5):623–5.

Moraes P de C, Teixeira RG, Tacchelli DP, Bonecker M, JUnqueira JoL, Oliveira LB. Atypical Case of Oral Lichen Planus in a Pediatric Patient: Clinical Presentation and Management Paulo. Pediatr Dent. 2011;33(5):445–7.

Saraceno R, Lorè B, Ventura A, Nisticò SP, Perugia C, Chimenti S, et al. Oral lichen planus: Novel acquisitions in the pathogenesis and treatment. Eur J Inflamm. 2013;11(3):601–8.

Gupta S, Jawanda MK. Oral Lichen Planus : An Update on Etiology, Pathogenesis, Clinical Presentation, Diagnosis and Management. Indian J Dermatol. 2015;222–9.

Liu C, Xie B, Yang Y, Lin D, Wang C, Lin M, et al. Efficacy of intralesional betamethasone for erosive oral lichen planus and evaluation of recurrence: A randomized, controlled trial. Oral Surg Oral Med Oral Pathol Oral Radiol [Internet]. 2013;116(5):584–90. Available from: http://dx.doi.org/10.1016/j.oooo.2013.07.023

Xia J, Li C, Hong Y, Yang L, Huang Y, Cheng B. Short-term clinical evaluation of intralesional triamcinolone acetonide injection for ulcerative oral lichen planus. J Oral Pathol Med. 2006;35(6):327–31.

Riano Arguelles A, Martino Gorbea R, Iglesias Zamora ME, Garatea Crelgo J. Topic tacrolimus, alternative treatment for oral erosive lichen planus resistant to steroids: a case report. Med Oral Patol Oral Cir Bucal. 2006;11(6):462–6.

Lee YC, Shin SY, Kim SW, Eun YG. Intralesional Injection versus Mouth Rinse of Triamcinolone Acetonide in Oral Lichen Planus: A Randomized Controlled Study. Otolaringol Neck Surg XX(X). 2013;1–7.

Thongprasom K, Prapinjumrune C, Carrozzo M. Novel therapies for oral lichen planus. J Oral Pathol Med. 2013;42(10):721–7.

Xiong C, Li Q, Lin M, Li X, Meng W, Wu Y, et al. The efficacy of topical intralesional BCG-PSN injection in the treatment of erosive oral lichen planus : a randomized controlled trial. J Oral Pathol Med. 2009;551–8.

Sanghavi J, Aditya A. Applications of Corticosteroids in Dentistry. J Dent Allied Sci. 2015;4(1):19.

Ogle OE, Santosh ABR. Medication Management of Jaw Lesions for Dental Patients. Dent Clin North Am. 2016;60(2):483–95.

Fantozzi PJ, Treister N, Shekar R. Intralesional triamcinolone acetonide therapy for inflammatory oral ulcers. Oral Surg Oral Med Oral Pathol Oral Radiol [Internet]. 2019;128(5):485–90. Available from: https://doi.org/10.1016/j.oooo.2019.07.024

PRISMA. PRISMA Statement [Internet]. 2009 [cited 2020 Feb 26]. Available from: http://www.prisma-statement.org/PRISMAStatement/.

Scopus. Journal Metrics [Internet]. 2017 [cited 2020 Mar 6]. Available from: https://journalmetrics.scopus.com/index.php/Faqs

Analytics C. Master Journal List Web of Science Group [Internet]. 2020 [cited 2020 Mar 6]. Available from: https://mjl.clarivate.com/search-results

DOAJ. Directory of Open Access Journal [Internet]. 2020 [cited 2020 Mar 6]. Available from: https://doaj.org/

Lee YC, Lee JS, Jung AR, Park JM, Eun Y-G. Factors Affecting the Result of Intralesional Corticosteroid Injection in Patients With Oral Lichen Planus. Clin Exp Otorhinolaryngol. 2018;11(3):205–9.

Mahmoud MM, Afifi MM. Anti-angiogenic therapy ( bevacizumab ) in the management of oral lichen planus. Egypt J Oral Sci. 2016;119–26.

Kuo R, Lin H, Sun A, Wang Y. Prompt healing of erosive oral lichen planus lesion after combined corticosteroid treatment with locally injected triamcinolone acetonide plus oral prednisolone. J Formos Med Assoc [Internet]. 2013;112(4):216–20. Available from: http://dx.doi.org/10.1016/j.jfma.2012.01.014

Nasr MM, Ebrahim HM, Khattab FM, Marei AM. Bacillus Calmette-Guerin , polysaccharide nucleic acid in the treatment of cutaneous and oral lichen planus. Dermatol Ther. 2018;(March 2017):1–4.

Metwalli MI, Marei AM, Toama M a, Soliman MI, Fawzy MM. Bacillus Calmette-Guerin polysaccharide nucleic acid extract versus triamcinolone acetonide intralesional injection in the treatment of oral lichen planus : a comparative study. Egypt J Dermatology Venereol. 2018;1–11.

Agha-Hosseini F. A New Approach for Treatment and Prevention of Recurrent Oral Lichen Planus: A Technical Report. J Islam Dent Assoc IRAN. 2018;30(3):126–31.

Golladay E. Treatment of Keloids by Single Intraoporative Perilesional Injec- tion of Repository Steroid. South Med J. 1988;81:736–8.

Firooz A, Tehranchi-Nia Z, Ahmed AR. Benefits and risks of intralesional corticosteroid injection in the treatment of dermatological diseases. Clin Exp Dermatol. 1995;20(5):363–70.

Hetland ML, Stengaard-Pedersen K, Junker P, Lottenburger T, Ellingsen T, Andersen LS, et al. Combination treatment with methotrexate, cyclosporine, and intraarticular betamethasone compared with methotrexate and intraarticular betamethasone in early active rheumatoid arthritis: An investigator-initiated, multicenter, randomized, double-blind, par. Arthritis Rheum. 2006;54(5):1401–9.

Monaco C, Andreakos E, Kiriakidis S, Feldmann M, Paleolog E. T-cell-mediated signalling in immune, inflammatory and angiogenic processes: The cascade of events leading to inflammatory diseases. Curr Drug Targets Inflamm Allergy. 2004;3(1):35–42.

Ismail SB, Kumar SKS, Zain RB. Oral lichen planus and lichenoid reactions: etiopathogenesis, diagnosis, management and malignant transformation. J Oral Sci. 2007;49(2):89–106.

Meilani D, Sinuraya RK. Pharmacovigilance Dalam Aspek Penanganan Reaksi Obat Yang Tidak Diinginkan: Sebuah Artikel Review. Farmaka [Internet]. 2018;16(Vol 16, No 1 (2018): Farmaka (Juni)):103–12. Available from: http://jurnal.unpad.ac.id/farmaka/article/view/17037

Katzung BG, Masters SB, Trevor AJ. Farmakologi Dasar & Klinik. Edisi 12. Vol. 1. Jakarta: EGC McGrawHill; 2012.

Gunawan SG, editor. Farmakologi dan Terapi. Edisi 6. Jakarta: Departemen Farmakologi Dan Terapeutik FKUI; 2016.




DOI: https://doi.org/10.33854/jbd.v9i2.1069

DOI (PDF (Bahasa Indonesia)): https://doi.org/10.33854/jbd.v9i2.1069.g443

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