Tatalaksana Radioterapi pada Kekambuhan Lokal Kanker Ovarium Clear Cell

Rhandyka Rafli

Abstract


Latar belakang: Kanker ovarium clear cell merupakan subtype jarang ditemukan. Kanker ovarium tidak memiliki gejala pada stadium awal sehingga lebih sering ditemukan pada stadium lanjut. Tatalaksana standar adalah dengan operasi sitoreduksi dilanjutkan dengan kemoterapi adjuvant Carboplatinum dan paclitaxel. Daya tahan dari sel punca kanker dan sifat kanker ovarium clear cell yang cenderung resisten berperan dalam kekambuhan lokal.  Radioterapi dapat berperan secara paliatif untuk mengurangi gejala dan meningkatkan kualitas hidup pasien. Radioterapi dapat diberikan dengan niat kuratif jika relaps terjadi secara lokal, peningkatan dosis dengan brakhiterapi dapat dipertimbangkan sebagai terapi lokal pada residu tumor terbatas. Laporan kasus: Seorang wanita berusia 34 tahun menjalani proses sectio caesarea pada kehamilan pertama aterm. Dalam durante operasi ditemukan massa berbenjol pada ovarium, sehingga diputuskan untuk dilakukan Histerek-Salphingo Oovorektomi Bilateral (HTSOB). Pemeriksaan histopatologi didapatkan jenis tumor adalah kanker ovarium clear cell. Kesimpulan: Radioterapi berperan secara palliative mengurangi gejala perdarahan, nyeri dan memperbaiki kualitas hidup pasien. Pada kanker ovarium clear cells radioterapi diberikan dengan tujuan kuratif dengan target lokal dan dapat diperttimbangkan pada kasus tertentu pemberian brakhiterapi  untuk peningkatan dosis.


Keywords


Clear cell carcinoma, kanker ovarium, Radioterapi

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References


Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;

Das PM, Bast Jr RC, for correspondence A. Early detection of ovarian cancer. Biomarkers Med. 2008;2(3):291–303.

Giornelli GH. Management of relapsed ovarian cancer: a review. Vol. 5, SpringerPlus. 2016. p. 1197.

Shu CA, Zhou Q, Jotwani AR, Iasonos A, Leitao MM, Konner JA, et al. Ovarian clear cell carcinoma, outcomes by stage: the MSK experience. Gynecol Oncol. 2015 Nov;139(2):236–41.

Rosen DG, Yang G, Liu G, Mercado-Uribe I, Chang B, Xiao XS, et al. Ovarian cancer: pathology, biology, and disease models. Front Biosci (Landmark Ed. 2009 Jan 1;14:2089–102.

Glasspool RM, McNeish IA. Clear Cell Carcinoma of Ovary and Uterus. Curr Oncol Rep. 2013 Dec 11;15(6):566–72.

NCCN. Ovarian Cancer Including Fallopian Tube Cancer and Primary Peritoneal Cancer. Clin Pract Guidel. 2017;

Ledermann JA, Raja FA, Fotopoulou C, Gonzalez-Martin A, Colombo N, Sessa C. Newly diagnosed and relapsed epithelial ovarian carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2013 Oct 1;24(suppl 6):vi24–32.

Mabuchi S, Sugiyama T, Kimura T. Clear cell carcinoma of the ovary: molecular insights and future therapeutic perspectives. J Gynecol Oncol. 2016 May;27(3):e31.

Fields EC, McGuire WP, Lin L, Temkin SM. Radiation Treatment in Women with Ovarian Cancer: Past, Present, and Future. Front Oncol. 2017 Aug 21;7:177.

Rafli R, Gondhowiardjo S a, Kantaatmadja AB, Matondang S, Krisnuhoni E. The correlation between aldehyde dehydrogenase-1A1 level and tumor shrinkage after preoperative chemoradiation in locally advanced rectal cancer. Adv Mod Oncol Res. 2015 Dec 2;1(2):112–6.

Patel UB, Brown G, Rutten H, West N, Sebag-montefiore D, Glynne-jones R, et al. The Cancer Stem Cell Marker Aldehyde Dehydrogenase Is Required to Maintain a Drug-Tolerant Tumor Cell Subpopulation. PLoS One. 2013 Oct 4;6(2):464–8.

Rycaj K, Tang DG. Cancer stem cells and radioresistance. Int J Radiat Biol. 2014 Aug ;90(8):615–21.

Mousa L, Salem ME, Mikhail S. Biomarkers of Angiogenesis in Colorectal Cancer. Biomark Cancer. 2015;7(Suppl 1):13–9.

Benish M, Ben-Eliyahu S. Surgery as a double-edged sword: A clinically feasible approach to overcome the metastasis-promoting effects of surgery by blunting stress and prostaglandin responses. Vol. 2, Cancers. 2010. p. 1929–51.

Pectasides D, Pectasides E, Psyrri A, Economopoulos T. Treatment Issues in Clear Cell Carcinoma of the Ovary: A Different Entity? Oncologist. 2006 Nov 1;11(10):1089–94.

Eleje GU, Eke AC, Igberase GO, Igwegbe AO, Eleje LI. Palliative interventions for controlling vaginal bleeding in advanced cervical cancer. Cochrane Database Syst Rev. 2019 Mar 19;

Kondoh C, Shitara K, Nomura M, Takahari D, Ura T, Tachibana H, et al. Efficacy of palliative radiotherapy for gastric bleeding in patients with unresectable advanced gastric cancer: a retrospective cohort study. BMC Palliat Care. 2015 Dec 4;14(1):37.

Kim J, Kim J, Bae J-S. ROS homeostasis and metabolism: a critical liaison for cancer therapy. Exp Mol Med. 2016;48(11):e269.




DOI: https://doi.org/10.33854/heme.v1i2.240

DOI (PDF): https://doi.org/10.33854/heme.v1i2.240.g190

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