Comparison of Quality of Life During Hormonal Therapy and Chemotherapy in Breast Cancer Patients at Dr. Moewardi Hospital: A Cross-Sectional Study
DOI:
https://doi.org/10.33854/heme.v8i2.1906Keywords:
Quality of Life, Breast Cancer, Hormonal Therapy, ChemotherapyAbstract
Introduction: Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer-related death among women worldwide, accounting for 25% of all cancer cases and 15% of cancer-related mortality in women. Adjuvant therapies include chemotherapy, hormonal therapy, targeted therapy, radiation, or combinations thereof. The quality of life (QoL) of breast cancer patients varies depending on type of therapy, patient’s condition, and associated side effects. Evaluating QoL differences between hormonal therapy and chemotherapy is essential to assess treatment outcomes and guide clinical decisions. Methods: This cross-sectional study involved 240 breast cancer survivors treated at the Oncology Department of Dr. Moewardi Hospital. Selected participants using random sampling in two groups: 120 patients each groups undergoing chemotherapy and hormonal therapy. Data were collected through interviews and standardized questionnaires using the EORTC QLQ-C30 instrument. QoL data were categorized, and statistical analysis was performed using chi-square tests to examine associations between treatment type and QoL. Logistic regression was used to assess the strength of relationships between variables. Results: Groups receiving hormonal therapy, 116 (96.7%) reported good QoL, and 4 (3.3%) reported moderate QoL. In the chemotherapy group, 80 (66.7%) reported good QoL, 39 (32.5%) moderate, and 1 (0.8%) poor QoL. A statistically significant difference in QoL was observed between the two groups (p = 0.001). Dyspnoea was the only symptom that showed a significant association with treatment type (r = 0.208; p = 0.020). Across general health status, functional scales, and symptom scales, hormonal therapy was associated with better QoL outcomes than chemotherapy. Conclusion: There is a significant difference in the QoL of breast cancer patients undergoing hormonal therapy compared to chemotherapy. Hormonal therapy was a better overall QoL.References
. Ribi K, Luo W, Walley BA, Burstein HJ, Chirgwin J, Ansari RH, Salim M, van der Westhuizen A, Abdi E, Francis PA, Chia S, Harvey VJ, Giobbie-Hurder A, Fleming GF, Pagani O, Di Leo A, Colleoni M, Gelber RD, Goldhirsch A, Coates AS, Regan MM, Bernhard J. Treatment-induced symptoms, depression and age as predictors of sexual problems in premenopausal women with early breast cancer receiving adjuvant endocrine therapy. Breast Cancer Res Treat. 2020 Jun;181(2):347-359. doi: 10.1007/s10549-020-05622-5. Epub 2020 Apr 9. PMID: 32274665.
. van Lonkhuizen PJC, Frank W, Heemskerk AW, van Duijn E, de Bot ST, Mühlbäck A, Landwehrmeyer GB, Chavannes NH, Meijer E; HEALTHE-RND consortium. Quality of life, health-related quality of life, and associated factors in Huntington's disease: a systematic review. J Neurol. 2023 May;270(5):2416-2437. doi: 10.1007/s00415-022-11551-8. Epub 2023 Jan 30. PMID: 36715747; PMCID: PMC10129943.
. Wyld L, Reed MWR, Collins K, et al. Improving outcomes for women aged 70 years or above with early breast cancer: research programme including a cluster RCT. Southampton (UK): National Institute for Health and Care Research; 2022 Jun.
. Ganz PA, Desmond KA, Leedham B, Rowland JH, Meyerowitz BE, Belin TR. Quality of life in long-term, disease-free survivors of breast cancer: a follow-up study.JNatlCancerInst 2002;94:39-49.
. Johanes Parasian, Yuni Susilowati, Nuryanti Nuryanti, Zahrah Maulidia Septimar, & Siti Haeriyah. (2023). Hubungan Efek Samping Kemoterapi dengan Kualitas Hidup Pasien Kanker Payudara di Rumah Sakit Kanker Dharmais Provinsi DKI Jakarta Tahun 2023. Termometer: Jurnal Ilmiah Ilmu Kesehatan Dan Kedokteran, 2(1), 115–126. https://doi.org/10.55606/termometer.v2i1.2808
. Adamowicz K, Baczkowska-Waliszewska Z. Quality of life during chemotherapy, hormonotherapy or antiHER2 therapy of patients with advanced, metastatic breast cancer in clinical practice. Health Qual Life Outcomes. 2020 May 12;18(1):134. doi: 10.1186/s12955-020-01389-x. PMID: 32398097; PMCID: PMC7216605.
. Hermoso, L.G., Furlong, L.V., Román, S.S., Pérez, E.B., Castillejos, N.A., & Friedman, P. (2021). Does Treatment Impact on the Quality of Life in Breast Cancer Patients? A Comparative Study Between Treatments.
. Andreu, Y., Soto-Rubio, A., Ramos-Campos, M. et al. Impact of hormone therapy side effects on health-related quality of life, distress, and well-being of breast cancer survivors. Sci Rep 12, 18673 (2022). https://doi.org/10.1038/s41598-022-22971-x
. Dantzer, R., Meagher, M.W., & Cleeland, C.S. (2012). Translational approaches to treatment-induced symptoms in cancer patients. Nat Rev Clin Oncol, 9(7), 414-426. https://doi.org/10.1038/nrclinonc.2012.88
. Rattcliff, C.G., Lam, C.Y., Arun, B., Valero, V., & Cohen, L. (2014). Ecological momentary assessment of sleep,symptoms, and mood during chemotherapy for breast cancer. Psychooncology, 23(11), 1220-1228. https://doi.org/10.1002/pon.3
. Benderli Cihan, Y., & Öztürk, O. (2023). The effect of surgery and hormone therapy on quality of life in breast cancer patients receiving radiotherapy. Turkish journal of surgery, 39(3), 237–248. https://doi.org/10.47717/turkjsurg.2023.6087
. Kumar T, Dutta R R, Thakre S, et al. (October 28, 2023) Resistance to Resilience: Understanding Post-surgical Hormone Therapy in Breast Cancer Care. Cureus 15(10): e47869. doi:10.7759/cureus.47869
. Ferreira, A. R., Di Meglio, A., Pistilli, B., Gbenou, A. S., El-Mouhebb, M., Dauchy, S., Charles, C., Joly, F., Everhard, S., Lambertini, M., Coutant, C., Cottu, P., Lerebours, F., Petit, T., Dalenc, F., Rouanet, P., Arnaud, A., Martin, A., Berille, J., Ganz, P. A., … Vaz-Luis, I. (2019). Differential impact of endocrine therapy and chemotherapy on quality of life of breast cancer survivors: a prospective patient-reported outcomes analysis. Annals of oncology : official journal of the European Society for Medical Oncology, 30(11), 1784–1795. https://doi.org/10.1093/annonc/mdz298
. Javan Biparva, A., Raoofi, S., Rafiei, S., Pashazadeh Kan, F., Kazerooni, M., Bagheribayati, F., Masoumi, M., Doustmehraban, M., Sanaei, M., Zarabi, F., Raoofi, N., Beiramy Chomalu, Z., Ahmadi, B., Seyghalani Talab, F., Sadat Hoseini, B., Asadollahi, E., Mir, M., Deylami, S., Zareei, M., Sanaei, H., … Ghashghaee, A. (2024). Global quality of life in breast cancer: systematic review and meta-analysis. BMJ supportive & palliative care, 13(e3), e528–e536. https://doi.org/10.1136/bmjspcare-2022-003642
. Adamowicz, K., & Baczkowska-Waliszewska, Z. (2020). Quality of life during chemotherapy, hormonotherapy or antiHER2 therapy of patients with advanced, metastatic breast cancer in clinical practice. Health and quality of life outcomes, 18(1), 134. https://doi.org/10.1186/s12955-020-01389-x
. Wilcken N, Hornbuckle J, Ghersi D. Chemotherapy alone versus endocrine therapy alone for metastatic breast cancer. Cochrane Database of Systematic Reviews 2003, Issue 2. Art. No.: CD002747. DOI: 10.1002/14651858.CD002747
. Ramirez, A. G., Muñoz, E., Long Parma, D., Perez, A., & Santillan, A. (2020). Quality of life outcomes from a randomized controlled trial of patient navigation in Latina breast cancer survivors. Cancer medicine, 9(21), 7837–7848. https://doi.org/10.1002/cam4.3272
. Faroughi, F., Fathnezhad-Kazemi, A. & Sarbakhsh, P. Factors affecting quality of life in women with breast cancer: a path analysis. BMC Women's Health 23, 578 (2023). https://doi.org/10.1186/s12905-023-02755-9
. Paraskevi T. Quality of life outcomes in patients with breast cancer. Oncol Rev. 2012 Jan 30;6(1):e2. doi: 10.4081/oncol.2012.e2. PMID: 25992204; PMCID: PMC4419638.
. Lima EOL, Silva MM. Quality of life of women with locally advanced or metastatic breast cancer. Rev Gaúcha Enferm. 2020;41:e20190292. doi: https://doi. org/10.1590/1983-1447.2020.20190292
. Łukasiewicz, S., Czeczelewski, M., Forma, A., Baj, J., Sitarz, R., & Stanisławek, A. (2021). Breast Cancer-Epidemiology, Risk Factors, Classification, Prognostic Markers, and Current Treatment Strategies-An Updated Review. Cancers, 13(17), 4287. https://doi.org/10.3390/cancers13174287
. Davis SR, Panjari M, Robinson PJ, Fradkin P, Bell RJ. Menopausal symptoms in breast cancer survivors nearly 6 years after diagnosis. Menopause. 2014;21(10):1075-1081 1010.1097/GME.0000000000000219
. Hui, D., Maddocks, M., Johnson, M. J., Ekström, M., Simon, S. T., Ogliari, A. C., Booth, S., Ripamonti, C., & ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org (2020). Management of breathlessness in patients with cancer: ESMO Clinical Practice Guidelines†. ESMO open, 5(6), e001038. https://doi.org/10.1136/esmoopen-2020-001038
. Dano, D., Hénon, C., Sarr, O., Ka, K., Ba, M., Badiane, A., Thiam, I., Diene, P., Diop, M., Dem, A., Marino, P., Mancini, J., Annede, P., Gonçalves, A., Diouf, D., & Monneur, A. (2019). Quality of Life During Chemotherapy for Breast Cancer in a West African Population in Dakar, Senegal: A Prospective Study. Journal of global oncology, 5, 1–9. https://doi.org/10.1200/JGO.19.00106
. Hasanah U, Ahmad M, Prihantono P, Usman AN, Arsyad A, Agustin DI. The quality of life assessment of breast cancer patients. Breast Disease. 2024;43(1):173-185. doi:10.3233/BD-249008
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