Kasus Jarang Karsinoma Sekretori Kelenjar Liur: Penegakkan Diagnosis uang Tepat Tanpa Pemeriksaan Molekuler

Sri Wildanur Wildanur, Noza Hilbertina, Yessy Setiawati

Abstract


Karsinoma sekretori kelenjar liur adalah karsinoma tingkat rendah yang ditandai dengan kemiripan morfologis dengan karsinoma sekretori mammae dan fusi gen ETV6-NTRK3. Kami melaporkan kasus jarang seorang perempuan berusia 53 tahun dengan benjolan pada parotis sejak 6 bulan. Pemeriksaan histopatologi dari spesimen parotidektomi memperlihatkan proliferasi sel tumor membentuk struktur mikrokistik dengan lumen berisi sekret eosinofilik, sitoplasma granular eosinofilik dan bervakuol. Diagnosis banding utama karsinoma sekretorik adalah dengan karsinoma sel asinik derajat rendah. Keduanya dapat dibedakan dengan pemeriksaan histokimia PAS positif pada sekret dan imunohistokimia positif kuat untuk S100 serta negatif untuk DOG1. Identifikasi translokasi t(12;15) (p13;q25) merupakan standar emas untuk diagnosis. Pada sumber daya rendah di mana analisis molekuler tidak tersedia, maka pemeriksaan histopatologi dan menggunakan imunohistokimia merupakan alat kunci untuk menegakkan diagnosis yang tepat.


Keywords


Karsinoma sekretori, kelenjar parotis, immunohistokimia

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DOI: https://doi.org/10.33854/heme.v7i2.1668

DOI (PDF): https://doi.org/10.33854/heme.v7i2.1668.g609

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