ERITEMA MULTIFORME TERKAIT INFEKSI VIRUS DAN ALERGI: LAPORAN KASUS

Alamsyah Piliang, Devi Nasution, Wahyu Hidayat

Abstract


Introduction: Erythema Multiforme (EM) is an acute mucocutaneous inflammatory disease that is self-limiting and manifests itself on the skin, oral mucosa, and another mucosa. Erythema multiforme caused by Herpes Simplex Virus (HSV) infection was diagnosed as Herpes Associated Erythema Multiforme (HAEM). Case and Management: We report a case of EM in a male patient aged 23 years, with a serosanguinous crustal lesion, tend to bleed lips, as well as lesions multiple erosive on the labial mucosa. The patient had a history of fever and symptoms of the prodrome before the lesions appeared, pain when eating and drinking if the lesions appeared. The laboratory test results showed Total IgE: 713.0, IgG HSV1: Positive 100.7, and IgM HSV1: Negative 14.1. Based on the results of the history and clinical examination as well as supporting (IgG and IgE serological tests) a diagnosis of Herpes Associated Erythema Multiforme was made. Treatment with topical corticosteroids, antiseptic mouthwash, multivitamins, and petroleum jelly cream, showed significant improvement and reduction in clinical signs and symptoms in the first week of treatment. Conclusion: The combination of pharmacological and non-pharmacological treatment plays an important role in the advancement of HAEM treatment.


Keywords


Alergi, Infeksi Virus, Eritema multiforme

References


Muryah A, Sufiawati I. Successful treatment of herpes simplex-associated erythema multiforme with a combination of acyclovir and prednisone. J Dentomaxillofacial Sci. 2017;2(3):191–3.

Kamala K, Ashok L, Annigeri R. Herpes associated erythema multiforme. Contemp Clin Dent. 2011;2(4):372-5.

Kishore M, Panat SR, Aggarwal A, Upadhyay N, Agarwal N. Herpes associated erythema multiforme-a diagnostic dilemma. Int J Sci Study. 2013;01(02):82–6.

Kumar SM, Kumar HM, Kumar VS iv., Kumar SH ar. Herpes-associated erythema multiforme worsened by a Siddha drug, Alpinia galanga, in an 18-year-old man. BMJ Case Rep. 2015;2–4.

Sharma A, Singh HP, Kaur P, Gupta I. Management of Erythema Multiforme Secondary to Herpes simplex by Systemic Corticosteroid : A Case report. J Dent Sci. 2013;1(3):45–9.

Shah SN, Chauhan GR, Manjunatha BS, Dagrus K. Drug induced erythema multiforme: Two case series with review of literature. J Clin Diagnostic Res. 2014;8(9):ZH01–4.

Isaac Joseph T, Vargheese G, George D, Sathyan P. Drug induced oral erythema multiforme: A rare and less recognized variant of erythema multiforme. J Oral Maxillofac Pathol. 2012;16(1):145–8.

Samim F, Auluck A, Zed C, Williams PM. Erythema multiforme. A review of epidemiology, pathogenesis, clinical features, and treatment. Dent Clin North Am. 2013;57(4):583–96.

Hidayat LH. Herpes Associated-Erythema Multiforme (HAEM) In Young Adult. ODONTO Dent J. 2018;5(2):152–6.

Ongole R, Praveen. Textbook of Oral Medicine, Oral Diagnosis and Oral Radiology. 2 Edition. India: Elsevier; 2013. 174–177 p.

Jayachandran S, Jayaram V, Kuduva Ramesh SS. Clinical Approach And Management of Erythema Multiforme – Case Report. Clin Dent. 2020;12:26–30.

Scully C, Almeida OP de, Bagan J, Dios PD, Taylor AM, De Almeida OP, et al. Oral Medicine and Pathology at a Glance. USA: Wiley-Blackwell; 2010. 64–65 p.

Paulino L, Hamblin DJ, Osondu N, Amini R. Variants of Erythema Multiforme: A Case Report and Literature Review. Cureus. 2018;10(10):1–8.

Thongprasom K. Treatment of a Pregnant Patient with Herpes Associated Erythema Multiforme (HAEM): A case report. Acta Stomatol Croat. 2016;50(3):265–8.

Nuraeny N, Sufiawati I. Herpes Associated Erythema Multiforme ( Laporan Kasus ). ResearchGate. 2020;1–12.

Valenta R, Hochwallner H, Linhart B, PahrS. Food allergies: The basics. Gastroenterology. 2015;148(6):1120–31. doi.org/10.1053/j.gastro.2015.02.006

Glick M, Lockhart PB, Greenberg MS, Challacombe SJ. Burket’s Oral Medicine. Thirteenth. USA: John Wiley & Sons, Inc; 2021. 211–258 p.

Valenta R, Hochwallner H, Linhart B, Pahr S. Food allergies: The basics. Gastroenterology. 2015;148(6):1120-1131.e4.

Baldo BA, Pham NH. Mechanisms of Hypersensitivity. Drug Allergy. Springer; 2021. 59–137 p.

Regezi JA, Sciubba JJ, Jordan RCK. Oral Pathology: Clinical Pathologic Correlations. 7th Editio. St. Louis, Missouri: Elsevier; 2017. 52–79 p.

Thongprasom K, Sooampon S.

Effectiveness of Topical Steroids in Treating Herpes-Associated Erythema Multiforme and Review of Topical Steroids Erythema Multiforme and Review of Topical St. J Dent Indones. 2019;26(2):114–8.

Muryah AE, Sufiawati I. Successful treatment of herpes simplex-associated erythema multiforme with a combination of acyclovir and prednisone. J Dentomaxillofacial Sci. 2017;2(3):191–3.

Kumar SB. Chlorhexidine Mouthwash- A Review. J Pharm Bioall Sci. 2017;9(9):1450–2.

Ruslijanto H, Amtha R, Meiyanti, Marwati E, Febrina S. Obat Topikal Untuk Lesi mulut: Pemilihan dan Cara Aplikasi. Lilian Juwono, editor. Indonesia: Penerbit Buku Kedokteran EGC; 2019. 3–5 p.




DOI: https://doi.org/10.33854/jbd.v9i1.972

DOI (PDF (Bahasa Indonesia)): https://doi.org/10.33854/jbd.v9i1.972.g412

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