ERITEMA MULTIFORME TERKAIT INFEKSI VIRUS DAN ALERGI: LAPORAN KASUS

Authors

DOI:

https://doi.org/10.33854/jbd.v9i1.972

Keywords:

Alergi, Infeksi Virus, Eritema multiforme

Abstract

Introduction: Erythema Multiforme (EM) is an acute mucocutaneous inflammatory disease that is self-limiting and manifests itself on the skin, oral mucosa, and another mucosa. Erythema multiforme caused by Herpes Simplex Virus (HSV) infection was diagnosed as Herpes Associated Erythema Multiforme (HAEM). Case and Management: We report a case of EM in a male patient aged 23 years, with a serosanguinous crustal lesion, tend to bleed lips, as well as lesions multiple erosive on the labial mucosa. The patient had a history of fever and symptoms of the prodrome before the lesions appeared, pain when eating and drinking if the lesions appeared. The laboratory test results showed Total IgE: 713.0, IgG HSV1: Positive 100.7, and IgM HSV1: Negative 14.1. Based on the results of the history and clinical examination as well as supporting (IgG and IgE serological tests) a diagnosis of Herpes Associated Erythema Multiforme was made. Treatment with topical corticosteroids, antiseptic mouthwash, multivitamins, and petroleum jelly cream, showed significant improvement and reduction in clinical signs and symptoms in the first week of treatment. Conclusion: The combination of pharmacological and non-pharmacological treatment plays an important role in the advancement of HAEM treatment.

Author Biographies

Alamsyah Piliang, Universitas Padjajaran

Mahasiswa Program Pendidikan Spesialis Ilmu Penyakit Mulut Universitas Padjajaran, Bandung, Indonesia

Devi Nasution, Universitas Padjajaran, Bandung

Mahasiswa Program Pendidikan Spesialis Ilmu Penyakit Mulut Universitas Padjajaran, Bandung

Wahyu Hidayat, Universitas Padjajaran, Bandung

Departemen Ilmu Penyakit Mulut

References

Muryah A, Sufiawati I. Successful treatment of herpes simplex-associated erythema multiforme with a combination of acyclovir and prednisone. J Dentomaxillofacial Sci. 2017;2(3):191–3.

Kamala K, Ashok L, Annigeri R. Herpes associated erythema multiforme. Contemp Clin Dent. 2011;2(4):372-5.

Kishore M, Panat SR, Aggarwal A, Upadhyay N, Agarwal N. Herpes associated erythema multiforme-a diagnostic dilemma. Int J Sci Study. 2013;01(02):82–6.

Kumar SM, Kumar HM, Kumar VS iv., Kumar SH ar. Herpes-associated erythema multiforme worsened by a Siddha drug, Alpinia galanga, in an 18-year-old man. BMJ Case Rep. 2015;2–4.

Sharma A, Singh HP, Kaur P, Gupta I. Management of Erythema Multiforme Secondary to Herpes simplex by Systemic Corticosteroid : A Case report. J Dent Sci. 2013;1(3):45–9.

Shah SN, Chauhan GR, Manjunatha BS, Dagrus K. Drug induced erythema multiforme: Two case series with review of literature. J Clin Diagnostic Res. 2014;8(9):ZH01–4.

Isaac Joseph T, Vargheese G, George D, Sathyan P. Drug induced oral erythema multiforme: A rare and less recognized variant of erythema multiforme. J Oral Maxillofac Pathol. 2012;16(1):145–8.

Samim F, Auluck A, Zed C, Williams PM. Erythema multiforme. A review of epidemiology, pathogenesis, clinical features, and treatment. Dent Clin North Am. 2013;57(4):583–96.

Hidayat LH. Herpes Associated-Erythema Multiforme (HAEM) In Young Adult. ODONTO Dent J. 2018;5(2):152–6.

Ongole R, Praveen. Textbook of Oral Medicine, Oral Diagnosis and Oral Radiology. 2 Edition. India: Elsevier; 2013. 174–177 p.

Jayachandran S, Jayaram V, Kuduva Ramesh SS. Clinical Approach And Management of Erythema Multiforme – Case Report. Clin Dent. 2020;12:26–30.

Scully C, Almeida OP de, Bagan J, Dios PD, Taylor AM, De Almeida OP, et al. Oral Medicine and Pathology at a Glance. USA: Wiley-Blackwell; 2010. 64–65 p.

Paulino L, Hamblin DJ, Osondu N, Amini R. Variants of Erythema Multiforme: A Case Report and Literature Review. Cureus. 2018;10(10):1–8.

Thongprasom K. Treatment of a Pregnant Patient with Herpes Associated Erythema Multiforme (HAEM): A case report. Acta Stomatol Croat. 2016;50(3):265–8.

Nuraeny N, Sufiawati I. Herpes Associated Erythema Multiforme ( Laporan Kasus ). ResearchGate. 2020;1–12.

Valenta R, Hochwallner H, Linhart B, PahrS. Food allergies: The basics. Gastroenterology. 2015;148(6):1120–31. doi.org/10.1053/j.gastro.2015.02.006

Glick M, Lockhart PB, Greenberg MS, Challacombe SJ. Burket’s Oral Medicine. Thirteenth. USA: John Wiley & Sons, Inc; 2021. 211–258 p.

Valenta R, Hochwallner H, Linhart B, Pahr S. Food allergies: The basics. Gastroenterology. 2015;148(6):1120-1131.e4.

Baldo BA, Pham NH. Mechanisms of Hypersensitivity. Drug Allergy. Springer; 2021. 59–137 p.

Regezi JA, Sciubba JJ, Jordan RCK. Oral Pathology: Clinical Pathologic Correlations. 7th Editio. St. Louis, Missouri: Elsevier; 2017. 52–79 p.

Thongprasom K, Sooampon S.

Effectiveness of Topical Steroids in Treating Herpes-Associated Erythema Multiforme and Review of Topical Steroids Erythema Multiforme and Review of Topical St. J Dent Indones. 2019;26(2):114–8.

Muryah AE, Sufiawati I. Successful treatment of herpes simplex-associated erythema multiforme with a combination of acyclovir and prednisone. J Dentomaxillofacial Sci. 2017;2(3):191–3.

Kumar SB. Chlorhexidine Mouthwash- A Review. J Pharm Bioall Sci. 2017;9(9):1450–2.

Ruslijanto H, Amtha R, Meiyanti, Marwati E, Febrina S. Obat Topikal Untuk Lesi mulut: Pemilihan dan Cara Aplikasi. Lilian Juwono, editor. Indonesia: Penerbit Buku Kedokteran EGC; 2019. 3–5 p.

Downloads

Published

2022-06-13

Issue

Vol. 9 No. 1 (2022)

Section

Case Report

License

Authors who publish with this journal agree to the following terms:

  • Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  • Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  • Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).