HUBUNGAN PENYAKIT PERIODONTAL TERHADAP KELAHIRAN PREMATUR DAN BERAT BADAN LAHIR RENDAH – TINJAUAN PUSTAKA

Erdi Effendi Nasution, Rini Octavia Nasution

Abstract


Introduction: Periodontal disease can mediate systemic effects through the action of periodontal pathogenic bacteria and lipopolysaccharide will increase prostaglandin and cytokine production which can trigger preterm birth. Pregnant women with periodontitis have a significantly higher risk for preterm birth with low birth weight <37 weeks of gestation and birth weight <2.500 grams. However, periodontal therapy can significantly reduce the rate of premature low birth weight among women with periodontitis. This literature review aims to assess the relationship between maternal periodontal diseases on preterm and low birth weight. Literature Review: Periodontitis can act as a reservoir of microbes and inflammatory mediators that affect preterm birth. Several studies have revealed that mothers with periodontal pathogens will increase levels of IL-1β, IL-6, TNF-α and PGE2 that are produced locally through systemic circulation and induce acute phase response in the liver which is characterized by increased levels of C-reactive protein that can trigger a risk of low birth weight. Periodontitis can be a risk factor for preterm birth due to the presence of proinflammatory bacteria and cytokines in the bloodstream that can invade the membrane and placenta. The effectiveness of periodontal treatment to prevent preterm birth is influenced by the diagnostic severity of periodontitis, microbial community composition, and the period of treatment during pregnancy. Conclusion: Periodontal disease is an independent risk factor for preterm birth. Plaque control procedures during pregnancy can reduce the occurrence of preterm and low birth weight.

Keywords


Periodontal disease; preterm birth; low birth weight

References


Baskaradoss JK, Geevarghese A, Dosari AA. Causes of Adverse Pregnancy Outcomes and the Role of Maternal Periodontal Status – A Review of the

Literature. The Open Dentistry Journal 2012, 6: 79-84.

Puertas A, Fernandez AM, Blanc V, et al. Association of Periodontitis with Preterm Birth and Low Birth Weight: A Comprehensive Review. The Journal of Maternal-Fetal & Neonatal Medicine 2017, At: 01-09.

Ren H, Du M. Role of Maternal Periodontitis in Preterm Birth. Front. Immunol 2017, 8:139.

Govindaraju P, Venugopal S, Shivakumar MA, Sethuraman S, Ramaiah SK, Mukundan S. Maternal periodontal disease and preterm birth: A case-control study. J Indian Soc Periodontol. 2015;19(5):512- 515.

Jiang H, Su Y, Xiong X, et al. Prevalence and risk factors of periodontal disease among pre-conception chinese women. Reproductive Health. 2016;13(141).

Kierce EA, Rainchuso L. Adverse Pregnancy Outcomes and Maternal Periodontal Health. Int J Dent & Oral Heal 2017, 3:7, 69-73.

Michalowicz BS, Durand R. Maternal Periodontal Disease and Spontaneous Preterm Birth. Periodontology 2000 2007,44: 103–112.

Kementerian Kesehatan Republik Indonesia. Riset Kesehatan Dasar 2018. Badan Penelitian dan Pengembangan Kesehatan 2018: 99-101 dan 185-190.

Zi MY, Longo PL, Bueno-Silva B, Mayer MP. Mechanisms involved in the association between periodontitis and complications in pregnancy. Front Public Health. 2015; 2:290.

Hasegawa-Nakamura K, Tateishi F, Nakamura T, Nakajima Y, Kawamata K, Douchi T, et al. The possible mechanism of preterm birth associated with periodontopathic Porphyromonas gingivalis. J Periodontal Res (2011) 46(4):497– 504.10.1111/j.1600-0765.2011.01366.

Vanterpool SF, Been JV, Houben ML, Nikkels PG, De Krijger RR, Zimmermann LJ, et al. Porphyromonas gingivalis within placental villous mesenchyme and umbilical cord stroma is associated with adverse pregnancy outcome. PLoS One (2016) 11(1): e146157.10.1371/journal.pone.0146157.

Ye C, Katagiri S, Miyasaka N, Bharti P, Kobayashi H, Takeuchi Y, et al. The anti- phospholipid antibody-dependent and independent effects of periodontopathic bacteria on threatened preterm labor and preterm

birth. Arch Gynecol Obstet (2013) 288(1):65–72.10.1007/s00404-013- 2741.Madianos PN, Bobetsis YA, Offenbacher S. Adverse Pregnancy Outcomes (APOs) and Periodontal Disease: Pathogenic Mechanisms. J Clin Periodontol 2013, 40: S170 –S80.

Mesa F, Pozo E, O'Valle F, et al. Relationship Between Periodontal Parameters and Plasma Cytokine Profiles in Pregnant Woman with Preterm Birth or Low Birth Weight. Clin Oral Investig 2016, 20: 669-74.

Marla V, Srii R, Roy DK, et al. The Importance of Oral Health During Pregnancy: A Review. MedicalExpress (São Paulo, online) 2018, 5:mr18002.

Hemalatha VT, Manigandan T, Sarumathi T, Aarthi Nisha V, Amudhan A. Dental Considerations in Pregnancy-A Critical Review on the Oral Care. Journal of Clinical and Diagnostic Research: JCDR.

;7(5):948-53. DOI:10.7860/JCDR/2013/5405.2986.

American College of Obstetricians and Gynecologists Women’s Health Care Physicians Committee on Health Care for Underserved Women. Committee opinion no. 569: Oral health care during pregnancy and through the lifespan. Obstetrics and Gynecology 2013; 122:417-22.

Jeffcoat M, Parry S, Sammel M, et al. Periodontal infection and Preterm Birth: Successful Periodontal Therapy Reduces the Risk of Preterm Birth. BJOG An International Journal of Obstetrics and Gynaecology 2011, 118: 250–256.

Sanz M, Kornman K. Working Group 3 of Joint EFP/AAPw. Periodontitis and Adverse Pregnancy Outcomes: Consensus Report of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases. J Clin Periodontol 2013, 40: S164 –




DOI: https://doi.org/10.33854/jbd.v9i2.881

DOI (PDF (Bahasa Indonesia)): https://doi.org/10.33854/jbd.v9i2.881.g442

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