TERAPI GEN PADA PERAWATAN PERIODONTITIS DAN PERI-IMPLANTITIS : A REVIEW DAN IMPLIKASI MASA DEPAN

Authors

DOI:

https://doi.org/10.33854/jbd.v8i2.865

Keywords:

Gene Therapy, Periodontitis, Peri-implantitis, Regeneration

Abstract

Introduction: Periodontal disease is a chronic inflammatory condition that affects supporting tissue around the teeth which results in periodontal tissue damage. If left untreated, periodontal disease can cause tooth loss. When this condition occurs around dental implants, the disease is called peri-implantitis. Along with the development of science and technology, various treatments for periodontitis and peri-implantitis have also been found. One of them is gene therapy. Gene therapy is a treatment that is offered and is proven to provide maximum results. Therefore, in this review, we present gene therapy in the application of periodontal tissue and peri-implant regeneration. The purpose of this article is to review the literature on the current of gene therapy in treatment of periodontitis dan peri-implantitis. Review: Periodontitis and peri-implantitis treatment with gene therapy is based on treatment by transferring genetic material to introduce, suppress, or manipulate certain genes that direct a person to have his own cells to produce therapeutic agents. Gen therapy can achieve greater bioavability of growth factors in periodontal wound so that they have greater regenerative potential, both in-vivo and ex-vivo with viral and non-viral vectors. Conclusion: Within the limitation of this review, it was shown that gene therapy could be an alternative in overcoming the weakness of various growth factors and showed promising results.

Author Biographies

Muhammad Yudin, Periodontology Specialist Educational Program, Faculty Of Dentistry, Hasanuddin University, Indonesia

Periodontology

Sri Oktawati, Lecture of Periodontology Department, Faculty Of Dentistry, Hasanuddin University, Indonesia

Periodontology

References

Sood S, Gupta S, Mahendra A. Gene therapy with growth factors for periodontal tissue engineering-A review. Med Oral Patol Oral Cir Bucal. 2012;17(2):301–10.

Padial-Molina M, Rios HF. Stem Cells, Scaffolds and Gene Therapy for Periodontal Engineering. Curr Oral Heal Reports. 2014;1(1):16–25.

Thomas SJ, Pr A, Abraham S, Author C, Thomas ST. Current Concepts and Future Aspects of Gene Therapy in Periodontics. 2018;2(7):118–26.

Goker F, Larsson L, Del Fabbro M, Asa’ad F. Gene Delivery Therapeutics in the Treatment of Periodontitis and PeriImplantitis: A State of the Art Review. Int J Mol Sci. 2019;20(14).

Liu Z, Chen X, Zhang Z, Zhang X, Saunders L, Zhou Y, et al. Nanofibrous Spongy Microspheres to Distinctly Release miRNA and Growth Factors to Enrich Regulatory T Cells and Rescue Periodontal Bone Loss. ACS Nano. 2018;12(10):9785–99.

Ivanovski1 S, , P. Mark Bartold2 , Stan Gronthos3 and DWH. Tissue Engineering and Regeneration in Dentistry. Waddington RJ, Sloan AJ, editors. British; 2017. 132–146 p.

Astuti LA, Hatta M, Oktawati S, Natzir R, Dwiyanti R. Change of TGF-β1 gene expression and tgf-β1 protein level in gingival crevicular fluid and identification of plaque bacteria in a patient with recurrent localized gingival enlargement before and after gingivectomy. Case Rep Dent. 2018;2018:7–14.

Hao J, Cheng KCK, Kruger LG, Larsson L, Sugai J V., Lahann J, et al. Multigrowth Factor Delivery via Immobilization of Gene Therapy Vectors. Adv Mater. 2016;28(16):3145–51.

Fischer J, Kolk A, Wolfart S, Pautke C, Warnke PH, Plank C, et al. Future of local bone regeneration - Protein versus gene therapy. J Cranio-Maxillofacial Surg [Internet]. 2011;39(1):54–64. Available from: http://dx.doi.org/10.1016/j.jcms.2010.03.016

Tang H, Mattheos N, Yao Y, Jia Y, Ma L, Gong P. In-vivo osteoprotegerin gene therapy preventing bone loss induced by periodontitis. J Periodontal Res. 2015;50(4):434–43.

D’Mello S, Atluri K, Geary SM, Hong L, Elangovan S, Salem AK. Bone Regeneration Using Gene-Activated Matrices. AAPS J [Internet]. 2017;19(1):43–53. Available from: http://dx.doi.org/10.1208/s12248-016-

-2

Rios HF, Lin Z, Oh B, Park CH, Giannobile W V. Cell- and Gene-Based Therapeutic Strategies for Periodontal Regenerative Medicine. J Periodontol. 2011;82(9):1223–37.

Atasoy-Zeybek A, Kose GT. Gene therapy strategies in bone tissue engineering and current clinical applications. Adv Exp Med Biol. 2018;1119:85–101.

Hall J, Soransen RG, Wozney JM, Wikesjö UME. Bone formation at rhBMP-2-coated titanium implants in the rat ectopic model. J Clin Periodontol. 2007;34(5):444–51.

Park SY, Kim KH, Gwak EH, Rhee SH, Lee JC, Shin SY, et al. Ex-vivo bone

morphogenetic protein 2 gene delivery using periodontal ligament stem cells for enhanced re-osseointegration in the regenerative treatment of peri-implantitis. J Biomed Mater Res - Part A. 2015;103(1):38–47.

Larsson L, Decker AM, Nibali L, Pilipchuk SP, Berglundh T, Giannobile W V. Regenerative Medicine for Periodontal and Peri-implant Diseases. J Dent Res. 2016;95(3):255–66

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Published

2021-11-19

Issue

Volume 8, Nomor 2, September 2021 (Special Edition)

Section

Literature Review

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