PENCEGAHAN KEGAGALAN IMPLAN DENTAL YANG DISEBABKAN PERI- IMPLANTITIS DENGAN PENGGUNAAN CONCENTRATED GROWTH FACTOR
DOI:
https://doi.org/10.33854/jbd.v11i1.1597Keywords:
CGF, concentrated growth factor, peri-implantitis, peri-implantitis treatmentAbstract
Introduction: The destruction that occurs in peri-implantitis, if left untreated, can eventually lead to dental implant failure. Autogenous growth factor is prepared by centrifugation of whole blood samples and has been widely applied in wound healing and tissue regeneration. This platelet concentrate can be used alone or in combination with other biomaterials for soft tissue healing or bone formation. CGF (concentrated growth factor) is a derivative of PRF (platelet-rich fibrin) and has the same 3-dimensional structural complex as PRF. However, it contains more growth factors than PRF and has a more rigid fibrinogen structure. Aims: The objective of this systematic review is to obtain scientific data related to the use of concentrated growth factors in peri-implantitis treatment in order to avoid dental implant failure. Method: A total of 5,339 studies were initially identified from the three databases (Wiley, Researchgate and Google Scholar) between January 2018 and July 2023. Result: Three randomised clinical trials (RCTs) were selected for analysis. Conclusion: Concentrated Growth Factor (CGF) can be employed in combination with bone graft material for the treatment of peri-implantitis, with the objective to prevent dental implant failure that may result from peri-implantitis. However, it is not the sole recommended approach.References
Amornvit P, Rokaya D, Bajracharya S, Keawcharoen K, Supavanich W. Management of obstructive sleep apnea with implant retained mandibular advancement device. World J Dent. 2014;5(3):184-189. doi:10.5005/jp-journals-10015-1285
Moraschini V, Poubel LADC, Ferreira VF, Barboza EDSP. Evaluation of survival and success rates of dental implants reported in longitudinal studies with a follow-up period of at least 10 years: A systematic review. Int J Oral Maxillofac Surg. 2015;44(3):377-388. doi:10.1016/j.ijom.2014.10.023
Rokaya D, Srimaneepong V, Wisitrasameewon W, Humagain M, Thunyakitpisal P. Peri-implantitis update: Risk indicators, diagnosis, and treatment. Eur J Dent. 2020;14(4):672-682. doi:10.1055/s-0040-1715779
Berglundh T, Armitage G, Araujo MG, et al. Peri-implant diseases and conditions: Consensus report of workgroup 4 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J Clin Periodontol. 2018;45(June 2018):S286-S291. doi:10.1111/jcpe.12957
Tomasi C, Derks J. Etiology, occurrence, and consequences of implant loss. Periodontol 2000. 2022;88(1):13-35. doi:10.1111/prd.12408
Schwarz F, Ramanauskaite A. It Is All About Peri-implant Tissue Health. Periodontol 2000. 2022;(88):9-12. doi:10.1111/prd.12407
Tomasi C, Regidor E, Ortiz-Vigón A, Derks J. Efficacy of reconstructive surgical therapy at peri-implantitis-related bone defects. A systematic review and meta-analysis. J Clin Periodontol. 2019;46(S21):340-356. doi:10.1111/jcpe.13070
Jin R, Song G, Chai J, Gou X, Yuan G, Chen Z. Effects of Concentrated Growth Factor on Proliferation, Migration, and Differentiation of Human Dental Pulp Stem Cells In Vitro. J Tissue Eng. 2018;9. doi:10.1177/2041731418817505
Tabatabaei F, Aghamohammadi Z, Tayebi L. In Vitro and In Vivo Effects of Concentrated Growth Factor on Cells and Tissues. J Biomed Mater Res - Part A. 2020;108(6):1338-1350. doi:10.1002/jbm.a.36906
Wang L, Wan M, Li Z, Zhong N, Liang D, Ge L. A Comparative Study of Ehe effects of Concentrated Growth Factors in Two Different Forms on Osteogenesis in Vitro. Mol Med Rep. 2019;20(2):1039-1048. doi:10.3892/mmr.2019.10313
Huang L, Zou R, He J, Ouyang K, Piao Z.Comparing Osteogenic Effects Between
Concentrated Growth Factors and the Acellular Dermal Matrix. Braz Oral Res. 2018;32:e29. doi:10.1590/1807-3107bor-2018.vol32.0029
Isler SC, Soysal F, Ceyhanlı T, Bakırarar B, Unsal B. Efficacy of concentrated growth factor versus collagen membrane in reconstructive surgical therapy of peri-implantitis: 3-year results of a randomized clinical trial. Clin Oral Investig. 2022;26(8):5247-5260. doi:10.1007/s00784-022-04493-y
Heitz-Mayfield LJA, Salvi GE, Mombelli A, et al. Supportive peri-implant therapy following anti-infective surgical peri-implantitis treatment: 5-year survival and success. Clin Oral Implants Res. 2018;29(1):1-6. doi:10.1111/clr.12910
Isler SC, Soysal F, Ceyhanlı T, Bakırarar B, Unsal B. Regenerative Surgical Treatment of Peri-implantitis using Either a Collagen Membrane or Concentrated Growth Factor: A 12-month Randomized Clinical Trial. Clin Implant Dent Relat Res. 2018;20(5):703-712. doi:10.1111/cid.12661
Aghazadeh A, Rutger Persson G, Renvert S. A single-centre randomized controlled clinical trial on the adjunct treatment of intra-bony defects with autogenous bone or a xenograft: Results after 12 months. J Clin Periodontol. 2012;39(7):666-673. doi:10.1111/j.1600-051X.2012.01880.x
Isler S, Soysal F, Ceyhani T, Bakiraar B, Unsal B. Reconstructive Surgical therapy of peri- implantitis: 3- year results of a randomized clinical trial. Clin Oral Implants Res. 2020;30(S20):35. doi:10.1111/clr.30
Shetty M, Kalra R, Hegde C. Maxillary sinus augmentation with concentrated growth factors: Radiographic evaluation. J Osseointegration. 2018;10(4):109-114. doi:10.23805/JO.2018.10.04.01
Manoj S, Punit J, Chethan H, Nivya J. A study to assess the bone formed around immediate postextraction implants grafted with Concentrated Growth Factor in the mandibular posterior region. J Osseointegration. 2018;10(4):121-129. doi:10.23805/JO.2018.10.04.03
Liu R, Yan M, Chen S, Huang W, Wu D, Chen J. Effectiveness of Platelet-Rich Fibrin as an Adjunctive Material to Bone Graft in Maxillary Sinus Augmentation: A Meta-Analysis of Randomized Controlled Trails. Biomed Res Int. 2019;2019. doi:10.1155/2019/7267062
Srivastava S, Shekhar A, Chaturvedi A, Bhatia L. Effect Of Concentrated Growth Factors On Implant Stability , Osseointegration And Bone Density Around Implant Surface : A Randomized Control Study. 2023;12(10):1557-1563. doi:10.48047/ecb/2023.12.si10.00183
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